Fig. 3From: Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington’s diseaseEarly and transient perfusion alterations in the zQ175DN HET mice. (A) Mean midbrain absolute CBF maps in both WT and zQ175DN HET group at 3, 6 and 9 months of age; (B) RBA in predefined cortical and subcortical regions at 3, 6 and 9 months, represented with subject values of absolute CBF and a group mean ± SD (multiple two-sample T-test, p < 0.05, FDR corrected); (C) Longitudinal assessment of absolute CBF differences between genotypes in four regions (mixed effect model, p < 0.05); Significant difference after FDR correction * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001; CgCtx—Cingulate Cortex, Cl – Claustrum, InsCtx – Insular Cortex, M1/2Ctx – Motor Cortex 1/2, S1/2Ctx – Somatosensory Cortex 1/2, CPu – Caudate Putamen, GP – Globus PallidusBack to article page