Fig. 2

Brain perfusion differences in the zQ175DN HET mice at 13 months of age. (A) Mean midbrain absolute CBF maps in both WT and zQ175DN HET group and a statistical T-map from VBA, overlaid on the study-specific template, showing local differences between genotypes (Two-sample T-test, p < 0.05, uncorrected, k ≥ 10); (B) RBA in predefined cortical and subcortical regions, represented with subject values of absolute CBF and a group mean ± SD (multiple two-sample T-test, p < 0.05, uncorrected); CgCtx—Cingulate Cortex, Cl – Claustrum, InsCtx – Insular Cortex, M1/2Ctx – Motor Cortex 1/2, S1/2Ctx – Somatosensory Cortex 1/2, CPu – Caudate Putamen, GP – Globus Pallidus