Fig. 5

The results of the Oroboros O2k analysis were obtained for striatum tissue samples from wild-type (WT), MitoPark, and PT320-treated MitoPark mice at different ages using the mitochondrial-specific complex protocol. A Oroboros O2k representative tracings of 8 weeks old WT mice. B O2k representative tracings of 8-week old MP mice. C O2k representative tracings of 8 weeks old MP + PT320 mice. D-G Age-dependent (8w, 12w, 16w and 22w, respectively) mitochondrial-specific O2 flux during basal, mitochondrial complex linked (CI, CII, CIV) and non-mitochondrial respiration. One-way analysis of variance (ANOVA) followed by Bonferroni post hoc test for multiple comparisons. WT vs MP or MP+PT320: *, p < 0.01; **, p < 0.05; ***, p < 0.001; MP vs MP+PT320: #, p < 0.01; ##, p < 0.05; ###, p < 0.001