Fig. 4

TEM analysis of mitochondrial structural changes in the striatum region in wild-type (WT), MitoPark, and PT320-treated MitoPark mice. The mitochondrial structures can be divided into four types as detailed in Results. Type I is the normal structure of healthy mitochondria. Type IV is the most damaged mitochondria, with disrupted and discontinuous outer membranes and deficient cristae. The red arrows indicate the different types of mitochondria. A Representative TEM images of four types of mitochondrial morphologies. Scale bar: 500 nm (B) Representative TEM images of different stages of the mitochondria morphologies in three groups. Scale bar: 1 µm (C) Percent of mitochondria type in early stage. D Percent of mitochondria type in middle stage. E Percent of mitochondria type in late stage. One-way analysis of variance (ANOVA) followed by Bonferroni post hoc test for multiple comparisons. WT vs MP or MP+PT320: *, p < 0.01; **, p < 0.05; ***, p < 0.001; MP vs MP+PT320: #, p < 0.01; ##, p < 0.05; ###, p < 0.001. (N = 3)