Fig. 1

Changes in TH protein expression at three MitoPark and PT320-treated MP mouse PD stages. Results show at the level of the substantia nigra pars compacta (SNc), TH starts to decline during the middle stage. The PT320 treatment showed significant differences at the late stage. The TH expression of the striatum area showed little change at the early stage but substantial changes with PT320-treated groups in the middle and late stages, as compared to untreated MitoPark animals. A Representative immunofluorescent images of TH expression in the SNc. Scale bar: 0.5 mm (B) Western blot results of TH expression and C The statistical results in SNc. D Representative immunofluorescent images of TH expression in the striatum. Scale bar: 1 mm (E) Western blot results of TH expression and F The statistical results in striatum. One-way analysis of variance (ANOVA) followed by Bonferroni post hoc test for multiple comparisons. WT vs MP or MP+PT320: *, p < 0.05; **, p < 0.005; ***, p < 0.001; MP vs MP+PT320: #, p < 0.05; ##, p < 0.005. (N = 3-5)