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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: H19 knockdown suppresses proliferation and induces apoptosis by regulating miR-148b/WNT/β-catenin in ox-LDL -stimulated vascular smooth muscle cells

Fig. 4

miR-148b inhibitor reversed the effects of H19 knockdown on proliferation and apoptosis in HA-VSMCs. (a-c) HA-VSMCs transfected with si-con+anti-miR-con, si-con+anti-miR-148b, si-H19 + anti-miR-con, or si-H19 and anti-miR-148b were stimulated with 50 μg/ml ox-LDL for 24 h, followed by the measurement of miR-148b level (a), cell proliferative capability (b), colony formation ability (c). d-g HA-VSMCs transfected with si-con+anti-miR-con, si-H19 + anti-miR-con, or si-H19 and anti-miR-148b were stimulated with 50 μg/ml ox-LDL for 24 h, followed by the determination of PCNA and Ki-67 expressions (d), apoptotic cell percentage (e), caspase-3 activity (f), Bax and Bcl-2 expressions (g). Data are presented as mean ± SEM (n = 3) of at three independent experiments. *P < 0.05

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