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Fig. 8 | Journal of Biomedical Science

Fig. 8

From: The complexity of TRIM28 contribution to cancer

Fig. 8

TRIM28-PHD-mediated SUMOylation of VPS34 protein in response to stress conditions stimulates the phagophore formation. Acetylated HSP70 recruits TRIM28 E3 ligase for SUMOylation of VPS34 at Lys840 increasing VPS34 activity bound to BECLIN1. Consequently, this complex promotes phagophore formation

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Journal of Biomedical Science

ISSN: 1423-0127