Fig. 6
From: Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish
Effect of MEK2S219D on cell proliferation was analyzed in COS-1 cells and in transgenic zebrafish. a The pcDNA3-MEK2S219D-GFP and pcDNA3-GFP (control) plasmids was transfected to COS-1 cells and evaluated the cell numbers by trypan blue assay from 1 to 4 days post-transfection. Results represent the mean of three independent determinations. * p < 0.05. b H&E-stained section in papilloma (black-dots area) of transgenic zebrafish. c Ki-67 IHC staining in papilloma (black-dots area) of transgenic zebrafish