Fig. 3
From: Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish
Transient expressions of MEK1 and MEK2 driven by the krt14 promoter induced papillae formation in skin cells. Lateral view of pTol2-krt14-GFP (a), pTol2-krt14-MEK2-GFP (b), pTol2-MEK2S223A-GFP (c), pTol2-krt14-MEK2S219D-GFP (d), pTol2-krt14-MEK1-mCherry (e), and pTol2-krt14-MEK1S219D-GFP (f) plasmids, which were microinjected into 1-cell stage of zebrafish embryos and visualized at 3 days post-fertilization (dpf). The arrow indicates skin cell papillae and budding in the upper epidermis. The upper panel is a fluorescent image. The middle panel is merged fluorescent and bright-field images. The lower panel is an enlargement of the white box in the middle panel