Variant | Number of patients with the gene mutation (percentage); Median of RNA expression (delta CT) | P | ||
---|---|---|---|---|
Whole cohort | 60 years or younger, (n=69) | Older than 60 y/o, (n=44) | ||
NPM1 mut | 38 (33.33%) | 21 (30%) | 17 (38.64%) | 0.227 |
FLT3- ITD | 23 (20.18%) | 15 (21/43%) | 8 (18.18%) | 0.433 |
FLT3- TKD | 8 (7.02%) | 2 (2.86%) | 6 (13.64%) | 0.036* |
NPM1mut/FLT3- ITDneg | 22 (19.30%) | 11(15.71%) | 11 (25%) | 0.164 |
CEBPA a | 34 (30.36%) | 18 (26.09%) | 16 (37.20%) | 0.151 |
CEBPA Double mutation,b | 9 (78.04%) | 8 (11.59%) | 1 (2.23%) | 0.016* |
IDH1 c | 3 (3.75 %) | 2 (4%) | 1 (3.3%) | 0.686 |
IDH2 c | 8 (10 %) | 4 (8%) | 4 (13.2%) | 0.454 |
DNMT3A c | 12 (15 %) | 10 (25.641%) | 2 (4.88%) | 0.095 |
MLL | 7 (8.75%) | 4 (8%) | 3 (10%) | 0.528 |
Delta BDH2 d | 9.006 (4.53-12.36) | 9.051 (4.53-12.36) | 8.915 (6.4-12.15) | 0.102 |
ERG d | 10.595 (4.52-19.92) | 10.88 (5.17-19.92) | 9.74 (4.52-19.85) | 0.435 |
MN1 d | 13.25 (7.75-19.87) | 13.06 (7.76-19.87) | 13.25 (7.75-18.38) | 0.992 |
miR-181a d | 3.21 (−3.8-8.44) | 3.3 (−0.03-8.44) | 2.49 (−3.8-8.2) | 0.140 |
miR-3151 d | 12.685 (4.97-15.29) | 12.685 (9.16-15.07) | 12.6 (4.97-15.29) | 0.247 |